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Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by blowing past the Arizona Cardinals 38-10 on Monday night in Mexico City.
It was the fifth regular-season NFL game played in Mexico City and first since 2019. Technically a Cardinals home game, the festive, raucous announced crowd of 78,427 fans at Estadio Azteca heavily favored the 49ers, roaring particularly loud when Kittle and Deebo Samuel each scored on 39-yard touchdowns.
San Francisco (6-4) has won five of its last seven and is tied with the Seahawks at the top of the NFC West. Garoppolo had another efficient performance, completing 20 of 29 passes for 228 yards.
Deebo Samuel carries the ball against the Arizona Cardinals during the third quarter
Jimmy Garoppolo throws a pass during the first half of an NFL football game against the Arizona Cardinals
It was a tight game through much of the first half, but the 49ers pulled away in the second half, jumping ahead 24-10 early in the third quarter on a nifty end-around play. Samuel took the pitch and sprinted 39 yards, weaving through the Cardinals defense on his way to the end zone.
It capped a powerful eight-play San Francisco drive that included seven run plays. Aiyuk’s second touchdown catch of the night — this one from 14 yards out — put the 49ers up 31-10 later in the third.
Brandon Aiyuk and teammates celebrate his touchdown reception against the Arizona Cardinals
The Cardinals (4-7) played their second straight game without Pro Bowl quarterback Kyler Murray, who has been battling a sore hamstring. Backup Colt McCoy had a 3-1 record in spot starts over the past two seasons — including a win over the Rams last week — but couldn’t recreate the same magic in Mexico.
McCoy finished 24 of 34 passing for 218 yards and an interception. The 49ers hit him hard multiple times, connecting for three sacks
The 49ers took a 17-10 into the halftime break after Robbie Gould connected on a 39-yard field goal with 43 seconds remaining the second quarter. It capped a back-and-forth first half that saw the teams gain almost identical amounts of yardage: The 49ers had a 186-185 advantage.
Colt McCoy is sacked by San Francisco 49ers defensive tackle Kevin Givens during the second half
The Cardinals pushed ahead 3-0 midway through the first quarter on Matt Prater’s 40-yard field goal as both teams dealt with a steady rain that started around kickoff and continued through much of the first half.
The 49ers responded early in the second when Garoppolo hit Aiyuk over the middle for a 7-yard touchdown, capping a nine-play, 82-yard drive. San Francisco intercepted McCoy on the ensuing drive after a pass bounced off James Conner’s hand and was snatched out of the air by Jimmie Ward.
San Francisco capitalized three plays later when Garoppolo evaded pressure and lofted a pass to Kittle, who juked two Arizona defenders and then cruised into the end zone for a 39-yard touchdown and a 14-3 lead.
The cavernous Estadio Azteca — which is home to two of Mexico’s top soccer teams — sits at an altitude of about 7,200 feet, which is much higher than both San Francisco and Phoenix. The 49ers opted to train at altitude this week in Colorado, while the Cardinals decided to stay at their home practice facility in Tempe, Arizona.
Arizona’s defense looked gassed in the second half, missing several tackles as the game slowly got out of hand.
George Kittle (85) celebrates his touchdown reception against the Arizona Cardinals during the fourth quarter
Christian McCaffrey (23) carries the ball past Arizona Cardinals linebacker Tanner Vallejo (51)
Have a great night and come back on Thursday for more live NFL coverage
The final score from tonight's one-sided offensive explosion is 49ers 38 - Cardinals 10
With 7 seconds left before the two-minute warning that all but clinches tonight's game
Geroge Kittle takes a pass 32 yards to the endzone for his second touchdown of the game. Following the extra point the 49ers lead 38-10
Arizonia has had two of the last three drives end in turnovers on downs with the outlier being a punt
The score heading into the 4th quarter is 49ers 31 - Cardinals 10
Aiyuk catches a 13-yard touchdown pass to give the 49ers a 21-point lead.
An 8 play drive ends in a 39-yard touchdown rush from Deebo Samuel. Following the extra point San Francisco leads 24-10
Following the kickoff San Francisco will start off with the ball on their own 20-yard line
As the team's head to their locker rooms for half time the score is 49ers 17 - Cardinals 10
Following a successful 39- yard field goal the 49ers lead 17-10
San Francisco has the ball on the Cardinals 31-yard line on 2nd&6
James Conner made up for the interception with his 4th touchdown of the year. Following the missed extra point the score is 49ers 14 - Cardinals 10
Garoppolo passes to Kittle for 39 yards TOUCHDOWN
49ers safety Jimmy Ward makes a sliding interception after the ball bounces off James Conner's hands
Jimmy Garoppolo finds Brandon Aiyuk for a 7-yard touchdown. Following the extra point San Fran leads the game 7 - 3
The score at the end of the first is Cardinals 3 - 49ers 0
San Fran punts the ball but downs it inside the Cardinals 5-yard line
Matt Prater hits a 40-yard field goal to give the Cardinals a 3-0 lead
Colt McCoy hits Hopkins for a 17-yard gain
San Fransico is also unable to record a first down either and punt the ball back to the Cardinals for a touchback
Following a punt on the games opening drive the 49ers will start their first drive at their own 37-yard line
Following the opening kickoff Arizonia will start off the game with the ball at their own 25-yard line, as rain has begun falling
Tonight, we bring you the Arizonia Cardinals facing off against the San Fransico 49ers fr0m Mexico City
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