AstraZeneca faces up to £255million compensation bill for 'defective' Covid vaccine after pharma titan admitted it DOES cause ultra-rare blood clot side effect - as wife of victim says 'we're not going to give up'

More than £250million could be given to victims allegedly harmed by AstraZeneca's Covid vaccine, MailOnline can reveal today.

Fifty-one families are pursuing legal action against the pharmaceutical titan, arguing the 'defective' jab was to blame for their injuries and deaths of loved ones.

Lawyers involved in the huge legal battle think some victims could be in line for pay-outs worth up to £5million. 

As such, the total compensation bill – which would be footed by taxpayers because of a deal AstraZeneca struck with the Government before the roll-out commenced – could theoretically reach £255m, if judges were to rule the vaccine was to blame for all of the injuries and deaths involved in the class action.

However, claims have yet to be fully quantified and some cases could eclipse or fall much short of the estimated £5million. 

One of those seeking compensation for injuries linked to the AstraZeneca Covid vaccine is father-of-two and IT engineer Jamie Scott (right), His wife Kate (left) said she hoped the new AstraZeneca submission was sign the legal case could be resolved soon 

Drugs giant AstraZeneca faces a landmark High Court battle over accusations that some doses of its Covid-19 vaccine were 'defective'

Researchers tasked with investigating the adverse reaction believe it occurs due to the modified cold virus lurking in the jab acting like a magnet to a type of protein in the blood called platelet factor 4. Platelet factor 4 is normally used by the body to promote coagulation in the blood, in case of injury. Then, in rare instances, the body's immune system confuses platelet factor 4 with a foreign invader and releases antibodies to attack it in case of 'mistaken identity'. These antibodies then clump together with platelet factor 4, forming the blood clots that have become so heavily linked with the jab, according to their theory

Some might not be proven to be down to the vaccine, which was given to millions of Britons. Deadly side effects were extraordinarily rare. 

The revelation at the potential compensation bill comes after AstraZeneca admitted – for the first time – that its vaccine could cause a blood clotting syndrome linked to some of the lawsuits.

Cambridge-based AstraZeneca, which is contesting the legal battle, acknowledged in a legal document submitted to the High Court in February that its vaccine 'can, in very rare cases, cause TTS'.

TTS is short for thrombosis with thrombocytopenia syndrome – a medical condition where a person suffers blood clots along with a low platelet count. Platelets typically help the blood to clot.

READ MORE: How safe is AstraZeneca's Covid jab? What rare complications can it cause? Who is taking legal action against the pharma giant? All you need to know 

As survivors and the bereaved keep fighting for compensation, MailOnline answers all your questions on the AstraZeneca saga: What happened? Are there any ongoing health concerns? And what are victims fighting for?

AstraZeneca's admission could lead to pay-outs on a case-by-case basis.

One of those seeking compensation is for injuries linked to AstraZeneca's vaccine is father-of-two and IT engineer Jamie Scott.

He was left with a permanent brain injury following a blood clot and the bleed on the brain after getting the vaccine in April 2021. He has been unable to work since. 

His wife Kate told The Telegraph: 'The medical world has acknowledged for a long time that VITT was caused by the vaccine. 

'It’s only AstraZeneca who have questioned whether Jamie’s condition was caused by the jab. 

'I hope their admission means we will be able to sort this out sooner rather than later.

'We need an apology, fair compensation for our family and other families who have been affected. 

'We have the truth on our side, and we are not going to give up.'

TTS, or vaccine-induced immune thrombotic thrombocytopenia (VITT), is thought to be linked to at least 81 deaths in the UK. 

Not all are proven, however. And not every family is seeking legal action. 

The complication is exceedingly rare, given the millions of doses dished out during the roll-out. 

Taxpayers will foot the bill of any potential settlement because of an indemnity deal AstraZeneca struck with the Government in the darkest days of Covid to get the jabs produced as quickly as possible while the country was paralysed by lockdowns. 

It comes just days after the firm reported a revenue exceeding £10billion in the first quarter of 2024, a rise of 19 per cent. Company officials stated it had enjoyed a 'very strong start' to the year. 

AstraZeneca said in a statement: 'Our sympathy goes out to anyone who has lost loved ones or reported health problems. 

'Patient safety is our highest priority, and regulatory authorities have clear and stringent standards to ensure the safe use of all medicines, including vaccines.

'From the body of evidence in clinical trials and real-world data, the AstraZeneca-Oxford vaccine has continuously been shown to have an acceptable safety profile and regulators around the world consistently state that the benefits of vaccination outweigh the risks of extremely rare potential side effects.'

The vaccine, developed in partnership with Oxford University, was heralded for its role in the UK's fightback against Covid, with more than 150million doses administered to date

The graph shows the cumulative number of Covid jabs dished out in the UK since the pandemic began, the percentage of each age group which has had a jab (bottom left) and the number of each Covid vaccine brand dished out

The new documents submitted to the court marks a change of language from the previous AstraZeneca submissions made last year, when it claimed that TSS couldn't be caused by its jab 'at a generic level'.

Its new submission also adds that the trigger that causes some people to suffer TSS from the AstraZeneca jab is unknown and can also occur in people independent of any vaccine.

It claims: 'Causation in any individual case will be a matter for expert evidence.' 

Similar action to that being taken by British families is understood to be underway in other countries where the AstraZeneca jab was deployed, including in Germany and Italy. 

AstraZeneca denies its new submission represents a U-turn on acknowledging its jab can cause TTS in court documents.

Lawyers representing victims and families are suing AstraZeneca under the Consumer Protection Act 1987.

READ MORE: An 18-year-old aspiring paramedic, a rock musician and an award-winning BBC radio presenter: The 'victims' of AstraZeneca's Covid vaccine

As families and survivors continue their fight for compensation, MailOnline highlights just some of those who have died

They argue the vaccine was 'a defective product' that was 'not as safe as consumers generally were reasonably entitled to expect'. AstraZeneca has strongly denied these claims. 

Health officials first identified cases of VITT linked to AstraZeneca's jab in Europe as early as March 2021, just over two months after the vaccine was first deployed in the UK. 

However, it wasn't until April that year that evidence became clear enough that the jab started to be restricted.

Spooked officials first restricted the jab to only people over 30. They then narrowed this to only over-40s in May 2021.

As the vaccine still worked against Covid, it was still deemed worth giving to older Brits who were at greater risk of death or injury from falling ill with the virus.

About 50million doses of the AstraZeneca jab were dished out in the UK in total.

Official data shows at least 81 Brits have died from blood clot complications apparently linked to the AstraZeneca jab, according to figures collected by the UK's drug watchdog, the Medicines and Healthcare products Regulatory Agency.

A further unconfirmed number have been injured and/or disabled. 

Further Covid vaccine rollouts have either minimised use of the AstraZeneca jab and/or phased it out entirely in favour of mRNA alternatives like those made by rival pharma giants Pfizer and Moderna. 

With health officials not ordering any more doses, this effectively means the jab has all but been withdrawn in the UK. 

The risk of TTS following AstraZeneca's Covid vaccine is thought to be in the region of one in 50,000. 

However, AstraZeneca's jab is credited with saving some 6million lives globally during the Covid pandemic. 

Victims and families seeking compensation that MailOnline has spoken to staunchly insist they believe in the merits of vaccination for public good and aren't anti-vaxxers. 

The reasons why people are taking legal action are complex.

Some who are severely disabled are facing huge ongoing medical costs as well as being out of work. In some cases, their family members are also having to quit employment to provide them round-the-clock care. 

Others are, at least in part, pursuing the action as way of seeking justice for either those they have lost or lives that have been completely upturned by their injuries. 

The AstraZeneca vaccine is a genetically engineered common cold virus that used to infect chimpanzees. It has been modified to make it weak so it does not cause illness in people and loaded up with the gene for the coronavirus spike protein, which Covid-19 uses to invade human cells

Melle Stewart and her husband Ben Lewis were enjoying successful careers in theatre before Covid struck and were keen to get vaccinated to help the UK return to normal

But Ms Stewart suffered a devastating stroke resulting from a extremely rare but incredibly dangerous complication linked to the AstraZeneca Covid vaccine 

Part of the reason some are seeking action is due to what critics have labelled as the inadequate or arbitrary nature of the Government's vaccine damage payment scheme.

This policy, which has been around since the 70s, offers people, or their families, a tax-free sum of £120,000, though restrictions apply.

It is only available to the family of those who died or those left 'severely disabled' — defined as being at least 60 per cent disabled, based on evidence from a doctor — because of a vaccine.

Established back in 1979, the scheme is meant to reassure people that, in the unlikely event something goes wrong, the state will provide support.

In theory, it is meant to combat vaccine hesitancy and encourage the public to get jabbed from various pathogens helping protect the nation from disease.

But critics have said the scheme is arduous, stingy in terms of total amount payout, and cruel in its 60 per cent disability threshold that leaves people less severely injured with nothing. 

As it is not compensation, people who take the payment are still entitled to take legal action against a vaccine manufacturer if they choose, as some people affected by the AstraZeneca jab are. 

Campaigners hope the attention brought by the AstraZeneca case will spark a much-needed rethink of how the nation's vaccine injured and bereaved are supported.

If Brits are left destitute from vaccine-derived injuries, experts fear this will fuel vaccine hesitancy in the future, risking public health from a variety of preventable diseases.

It could also leave people vulnerable to a potential future pandemic from a novel virus if some refuse the jabs out of fear that they, or their families, could be left financially ruined if something goes wrong.

Mrs Scott is one of critics of the system, previously saying: 'Even if we do get the £120,000 payment, it's not enough to keep us going for ever. And it's insulting, considering what Jamie has been through,' she said. 

Another of those pursuing action against AstraZeneca is Melle Stewart, an Australian actor who got the company's Covid jab while living in the UK. 

In February 2020, just weeks before Covid ripped across the globe, Melle Stewart was enjoying standing ovations in Belfast for her role in the musical 'Kiss Me, Kate'.

But after suffering a devastating stroke the 42-year-old struggles to put a sentence together, speaking only slowly, and 'grieving' for the successful stage career she has lost.

Ms Stewart is taking AstraZeneca to court, with husband Ben Lewis saying they felt misled by the Government over the jab's safety.

Though having suffered greatly, she was and continues to be a 'staunch and proud' advocate for vaccination, having gone on to receive other non-AstraZeneca Covid vaccines since her injury.