Charlie Sheen's ex Brooke Mueller is being quizzed by cops over Matthew Perry's ketamine death as investigators say 'multiple people' may be charged

Charlie Sheen's former wife Brooke Mueller has been interviewed 'multiple times' by the LAPD in relation to Matthew Perry's death after the pair reportedly bonded during stays in rehab, a new report says. 

Mueller was never arrested or handcuffed regarding the inquiries with sources telling InTouch that she has been co-operating with the criminal investigation. 

'She's hired lawyers and has had multiple meetings with law enforcement since they arrived at her sober living house with a search warrant. She's being tight-lipped about the situation,' a source told the magazine. 

This development comes following separate report that said investigators could charge 'multiple people' in relation to the actor's death. DailyMail.com has reached out to Mueller for comment on this story. 

'It's tough to say or know exactly what her role is [in Matthew's death], but she's adamant she had nothing to do with that.'

Mueller, 46, has had various issues with substance abuse over the years. In July 2011, she underwent a rehab program. Two years later, her children were removed from her home because of suspected drug use. Mueller reentered rehab at that time.

Brooke Mueller, 46, was married to troubled actor Charlie Sheen between 2008 and 2011, the couple has three children together 

Matthew Perry pictured in his hot tub in his final Facebook post prior to his October 2023 death 

Perry, shown here in 2015, died due to the 'acute effects of ketamine,' an autopsy found

Her last public rehab stint occurred in August 2019. Between 2008 and 2011, Mueller was married for actor Charlie Sheen. The couple has twin sons together, Bob and Max. Their divorce came amid allegations of domestic abuse on Sheen's part. 

Perry's death in October 2023 at the age of 54 shocked the world. The beloved Friends star was unresponsive in his hot tub in his Los Angeles home. An autopsy attributed his death to the 'acute effects of ketamine.'

The amount of ketamine in his blood was in the range used for general anesthesia during surgery. It was listed as the primary cause of death, which was ruled an accident with no foul play suspected, the report said. 

People close to the actor told coroner's investigators that he was undergoing ketamine infusion therapy. The decades-old surgical drug has seen a huge surge in use in recent years as a treatment for depression, anxiety and pain.

According to the InTouch report, investigators in the case have seized a laptop and iPhone from Mueller.  

An insider confirmed to InTouch that Mueller and Perry met during rehab. 'They formed an unexpected friendship,' the friend said. 

Perry said in 2022 that he estimated that spent $9 million battling his addictions across 15 rehab stays.  

In a report by People published on Tuesday, an investigative source from law enforcement said that investigation is now 'nearing its conclusion.'

Brooke Mueller poses for her mugshot after being arrested and charged with assualt and possession of cocaine with intent to distribute on December 3, 2011

Mueller has had multiple stints in rehab, her most recent occurring in 2019 

 The source did not clarify who the 'multiple people' potentially facing charges are, adding that any future action will ultimately be determined by the U.S. Attorney's Office. 

In December last year, a medical expert speculated to Page Six the actor had 'likely' obtained ketamine illegally for 'recreational use,' however.

Even though Perry was undergoing ketamine treatment for anxiety and depression at the time of his passing, his autopsy report noted 'the ketamine in his system at death could not be from that infusion therapy.'

In collaboration with the DEA and the U.S. Postal Inspector, LAPD then started investigating where the ketamine came from that 'ended up playing a part' in the actor's death.

At the time, TMZ reported that an ongoing investigation was looking to deduce where the actor — who spent years battling alcoholism and drug addiction — got the ketamine.

'Law enforcement sources tell us there is an ongoing investigation into where Matthew got the ketamine that ended up playing a part in his death — and the main questions are who provided the drug, and under the circumstances,' the outlet reported.  

Sources also told the outlet that 'both local police and the DEA have been looking into this matter for months, but it's unclear where exactly investigators are in the probe.' 

It was also revealed that they had already talked to 'some key people in Hollywood,' who are 'known to have a history of drug use or abuse,' as they 'could have information leading to the source,' per the report. 

A year prior to his death, he opened up about his struggles with addiction and detailed his sobriety journey in his memoir Friends, Lovers, and the Big Terrible Thing. 

In the tell-all released in 2022, he claimed that he was finally sober after multiple failed attempts to get clean and at a personal cost of $9 million.  

Later, sources told DailyMail.com that the 'reclusive' star would have younger hook-ups from the dating app Raya to deliver drugs to his house even while he was under the 24/7 care of a nursing team.

Despite having a nursing team at his $6 million Pacific Palisades home as well as a live-in sober companion, Perry managed to have casual hook-ups sneak him illicit drugs without detection, sources explained in December 2023.

'He would meet girls on dating apps and have them come over,' insiders claimed.

'There was a slew of 21 to 25-year-olds that he would meet on Raya. They would bring drugs with them. It was mostly Oxycontin [a powerful opioid pain killer]. He would also get illicit drugs from old girlfriends, there was a kind of network,' a source said. 

The source added: 'I think with [his memoir], Matthew thought it would help him to get to the place that he was describing.

'He was writing about what he was hoping to be the situation as if he was already there. He was writing the script that he wanted.'